Effect of hydrogen-rich saline on mitochondrial permeability transition pore after focal cerebral ischemia reperfusion injury in rats
- Journal：江苏 医 药
- Disease Model：Cerebral ischemia and reperfusion
- Corresponding Author：崔苏扬(Suyang Cui)
- Corresponding Unit：The Affiliated Hospital of Nanjing University of Chinese Medicine
- Experimental Subject：Rats
- Way of Hydrogen Administration：Hydrogen rich saline, intraperitoneal injection
- Dosage：5 ml/kg
- Duration：Single Test
Compared with sham-operation group, nerve function deficit score of all groups rise 48 hours after reperfusion, mPTP activity increases, mitochondrial transmembrane potential is lowered and TUNEL positive cells increase. Compared model group, nerve function deficit score of hydrogen-rich group and hydrogen-rich water/atractyloside group declines, mPTP activity decreases, mitochondrial transmembrane potential rises and TUNEL positive cells decrease. Compared with hydrogen-rich group, nerve function deficit score of hydrogen-rich water/atractyloside group rises, mPTP activity increases, mitochondrial transmembrane potential is lowered and TUNEL positive cells increase.
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Molecular hydrogen is the smallest molecule known in nature, and it was regarded by the scientific community as the inert gas without biological effects. In 2007, Nature Medicine published a paper confirming that hydrogen inhalation can protect cerebral ischemia-reperfusion injury. As of now, nearly 1200 relevant papers have been published internationally confirming the biological effects of hydrogen, and involving 63 kinds of important human diseases.